Headache in thrombotic thrombocytopenic purpura: two cases with pathophysiological considerations.

Abstract

Headache is one of the most common neurological symptoms reported by patients with thrombotic thrombocytopenic purpura (TTP). Reports of headache characteristics in patients with TTP are rare. We report 2 cases of headache in a setting of TTP and review previous reports. Headache in TTP can have features in common with both migraine and tension-type headache. Although the pathophysiology of headache in TTP is not certain, platelet aggregation and activation may play a key role.

• Authors: David Bezov, Richard B Lipton, Nikolai Podoltsev, Chi G Zhao, Sait Ashina
• Journal: Headache (Headache) Vol. 50 Issue 6 Pg. 1060-4 (Jun 2010) ISSN: 1526-4610 [Electronic] United States
• PMID: 20487032 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Aged
• Female
• Headache (complications, physiopathology)
• Humans
• Male
• Purpura, Thrombotic Thrombocytopenic (complications, physiopathology)