Polymyxin-direct hemoperfusion for sepsis-induced multiple organ failure.

Abstract

We report a case of multiple organ failure caused by the Bacillus cereus infection during acute lymphoblastic leukemia therapy, who was treated successfully. A 15-year-old male developed (B. cereus) sepsis on the 19th day after chemotherapy initiation. Polymyxin-direct hemoperfusion for septic shock was started, followed by continuous hemodiafiltration. His condition improved after starting the hemoperfusion. At the onset of sepsis, elevated levels of serum inflammatory cytokines, anti-inflammatory cytokines, and plasminogen-activator inhibitor complex-1 were observed. Serum levels of these cytokines and bioactive substances decreased after blood purification therapy, which correlated with the improvement of clinical symptoms.

• Authors: Koichi Hirabayashi, Masaaki Shiohara, Shoji Saito, Miyuki Tanaka, Ryu Yanagisawa, Goro Tsuruta, Tetsuhiro Fukuyama, Yoshihiko Hidaka, Yozo Nakazawa, Takashi Shimizu, Kazuo Sakashita, Kenichi Koike
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 55 Issue 1 Pg. 202-5 (Jul 15 2010) ISSN: 1545-5017 [Electronic] United States
• PMID: 20486188 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cytokines
• Plasminogen Activator Inhibitor 1
• Polymyxins

Topics

• Adolescent
• Bacillus cereus (isolation & purification)
• Cytokines (blood)
• Hemodiafiltration (methods)
• Humans
• Male
• Multiple Organ Failure (etiology, therapy)
• Plasminogen Activator Inhibitor 1 (blood)
• Polymyxins (administration & dosage)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (therapy)
• Sepsis (complications, therapy)