Phosphate diesters cleavage mediated by Ce(IV) complexes self-assembled on gold nanoparticles.

Abstract

Monolayer protected gold nanoparticles (MPGN) coated with metal chelating groups were prepared. In the presence of Ce(IV), the MPGN proved to be highly active in promoting the hydrolytic cleavage of the DNA model bis-p-nitrophenyl phosphate (BNP). A 2.5 million-fold rate acceleration of the BNP hydrolysis was measured at a concentration of Ce(IV) as low as 120 microM (pH 7, 25 degrees C). This corresponds to a reduction of the substrate half-life time from 2000 years to few hours. The MPGN-Ce(IV) system is 1 to 2 orders of magnitude more reactive than any mono- and binuclear Ce(IV) complex so far reported. The source of such reactivity is the cooperation between the metal ions self-organized on the surface of the nanoparticles.

• Authors: Renato Bonomi, Paolo Scrimin, Fabrizio Mancin
• Journal: Organic & biomolecular chemistry (Org Biomol Chem) Vol. 8 Issue 11 Pg. 2622-6 (Jun 07 2010) ISSN: 1477-0539 [Electronic] England
• PMID: 20485797 (Publication Type: Journal Article)

Chemical References

• Esters
• Organometallic Compounds
• Phosphates
• Cerium
• Gold

Topics

• Cerium
• Esters (chemistry)
• Gold (chemistry)
• Hydrogen-Ion Concentration
• Kinetics
• Metal Nanoparticles (chemistry)
• Organometallic Compounds (chemistry)
• Phosphates (chemistry)