HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Aichi virus IgG seroprevalence in Tunisia parallels genomic detection and clinical presentation in children with gastroenteritis.

Abstract
Aichi virus has been described as a novel causative agent of gastroenteritis in humans. In this study, we report the seroprevalence distribution of Aichi virus in Tunisia. A panel of 1,000 sera was screened by applying an enzyme-linked immunosorbent assay for immunoglobulin G specific for Aichi virus. A considerable prevalence (92%) of antibody to Aichi virus was found across all age groups. The specific anti-Aichi virus antibodies increased with age, from a high rate (68.8%) in children under 10 years old to about 100% in persons more than 60 years old. We found a statistically significant increase in levels of antibody to Aichi virus according to the age of patients. Immunoglobulin M antibodies were detected among five children. A high frequency of Aichi virus monoinfections in hospitalized children with severe gastroenteritis was previously observed in Tunisia. Aichi virus causes diarrhea with dehydration, fever, and vomiting. This work is the first to establish a correlation between the high seroprevalence of specific Aichi virus antibodies, clinical presentation, and a high frequency of isolation of Aichi virus by genomic characterization in stools of children suffering from gastroenteritis. Our data show the importance and emerging character of Aichi virus in the viral etiology of pediatric gastroenteritis.
AuthorsKhira Sdiri-Loulizi, Mouna Hassine, Jean-Baptiste Bour, Katia Ambert-Balay, Maha Mastouri, Ludwig-Serge Aho, Hakima Gharbi-Khelifi, Zaidoun Aouni, Nabil Sakly, Slaheddine Chouchane, Mohamed Neji-Guédiche, Pierre Pothier, Mahjoub Aouni
JournalClinical and vaccine immunology : CVI (Clin Vaccine Immunol) Vol. 17 Issue 7 Pg. 1111-6 (Jul 2010) ISSN: 1556-679X [Electronic] United States
PMID20484569 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Viral
  • Immunoglobulin G
Topics
  • Adolescent
  • Adult
  • Age Factors
  • Antibodies, Viral (blood)
  • Child
  • Diarrhea
  • Enzyme-Linked Immunosorbent Assay
  • Fever
  • Gastroenteritis (diagnosis, epidemiology, virology)
  • Genome, Viral
  • Humans
  • Immunoglobulin G (immunology)
  • Kobuvirus (isolation & purification)
  • Middle Aged
  • Seroepidemiologic Studies
  • Tunisia (epidemiology)
  • Vomiting
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: