Oxidative stress, molecular inflammation and sarcopenia.

Abstract

Sarcopenia is the decline of muscle mass and strength with age. Evidence suggests that oxidative stress and molecular inflammation play important roles in age-related muscle atrophy. The two factors may interfere with the balance between protein synthesis and breakdown, cause mitochondrial dysfunction, and induce apoptosis. The purpose of this review is to discuss some of the major signaling pathways that are activated or inactivated during the oxidative stress and molecular inflammation seen in aged skeletal muscle. Combined interventions that may be required to reverse sarcopenia, such as exercise, caloric restriction, and nutrition, will also be discussed.

• Authors: Si-Jin Meng, Long-Jiang Yu
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 11 Issue 4 Pg. 1509-26 (Apr 12 2010) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 20480032 (Publication Type: Journal Article, Review)

Chemical References

• Protein Kinases

Topics

• Caloric Restriction
• Exercise
• Humans
• Inflammation (metabolism)
• Mitochondria, Muscle (metabolism)
• Oxidative Stress
• Protein Kinases (metabolism)
• Sarcopenia (metabolism, pathology, prevention & control)
• Signal Transduction