Abstract |
Marine sponges are an excellent source of bioactive secondary metabolites with potential therapeutic value in the treatment of diseases. One group of compounds of particular interest is the microtubule- stabilizing agents, the most well-known compound of this group being paclitaxel ( Taxol), an anti- cancer compound isolated from the bark and leaves of the Pacific yew tree. This review focuses on two of the more recent additions to this important class of drugs, peloruside A and zampanolide, both isolated from marine sponges. Peloruside A was isolated from Mycale hentscheli collected in New Zealand coastal waters, and it already shows promising anti- cancer activity. Two other potent bioactive compounds with different modes of action but isolated from the same sponge, mycalamide A and pateamine, will also be discussed. The fourth compound, zampanolide, most recently isolated from the Tongan sponge Cacospongia mycofijiensis, has only recently been added to the microtubule-stabilizing group of compounds, and further work is in progress to determine its activity profile relative to peloruside A and other drugs of this class.
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Authors | John H Miller, A Jonathan Singh, Peter T Northcote |
Journal | Marine drugs
(Mar Drugs)
Vol. 8
Issue 4
Pg. 1059-79
(Mar 31 2010)
ISSN: 1660-3397 [Electronic] Switzerland |
PMID | 20479967
(Publication Type: Journal Article, Review)
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Chemical References |
- Antineoplastic Agents
- Bridged Bicyclo Compounds, Heterocyclic
- Epoxy Compounds
- Lactones
- Macrolides
- Pyrans
- Thiazoles
- pateamine A
- peloruside A
- zampanolide
- mycalamide A
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Topics |
- Animals
- Antineoplastic Agents
(isolation & purification, pharmacology)
- Bridged Bicyclo Compounds, Heterocyclic
(isolation & purification, pharmacology)
- Epoxy Compounds
(isolation & purification, pharmacology)
- Humans
- Lactones
(isolation & purification, pharmacology)
- Macrolides
(isolation & purification, pharmacology)
- Microtubules
(drug effects)
- Neoplasms
(drug therapy, pathology)
- Porifera
(chemistry)
- Pyrans
(isolation & purification, pharmacology)
- Thiazoles
(isolation & purification, pharmacology)
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