Abstract | BACKGROUND: OBJECTIVE: The aim of this study is to investigate the mechanism(s) behind weight reduction by measuring energy expenditure and appetite sensations in overweight and obese individuals. DESIGN: Thirty-two healthy, overweight or moderately obese men were treated with 2.0 mg TE daily for 7 days followed by an additional 7 days with 1.0 mg TE daily or corresponding placebo (PL) in a randomized, controlled trial. They were instructed to maintain habitual food intake and physical activity throughout. Twenty-four-hour energy expenditure (24-h EE), fat oxidation and spontaneous physical activity were measured in a respiration chamber before and after treatment. Body composition was assessed by dual-energy X-ray absorption and appetite was evaluated by visual analogue scales in conjunction with a standardized dinner. RESULTS: Despite efforts to keep body weight and composition constant, TE induced a 1.8 kg weight loss above PL after 2 weeks' treatment (P<0.0001). TE also induced higher ratings of satiety and fullness and concomitantly lower prospective food intake than placebo. No significant effect of TE on total 24-h EE could be demonstrated compared with PL, but higher energy expenditure was observed during the night period (4.6%; P<0.05) when adjusted for changes in body composition. Furthermore, TE increased 24-h fat oxidation as compared with PL (18 g; P<0.001). CONCLUSION: TE has a pronounced effect on appetite sensations and a slight effect on energy expenditure at night-both effects can contribute to the strong weight-reducing effect of TE.
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Authors | A Sjödin, C Gasteyger, A-Lh Nielsen, A Raben, J D Mikkelsen, J K S Jensen, D Meier, A Astrup |
Journal | International journal of obesity (2005)
(Int J Obes (Lond))
Vol. 34
Issue 11
Pg. 1634-43
(Nov 2010)
ISSN: 1476-5497 [Electronic] England |
PMID | 20479765
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bridged Bicyclo Compounds, Heterocyclic
- Neurotransmitter Uptake Inhibitors
- Tesofensine
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Topics |
- Adolescent
- Adult
- Appetite
(drug effects, physiology)
- Bridged Bicyclo Compounds, Heterocyclic
(pharmacology)
- Double-Blind Method
- Energy Metabolism
(drug effects, physiology)
- Humans
- Male
- Middle Aged
- Neurotransmitter Uptake Inhibitors
(pharmacology)
- Obesity
(drug therapy, physiopathology)
- Overweight
(drug therapy, physiopathology)
- Treatment Outcome
- Young Adult
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