Insight into the inflammasome and caspase-activating mechanisms.

Abstract

Inflammasomes are recently discovered molecular complexes that can sense danger signals and specifically activate caspase-1 and -5 and proinflammatory cytokines (IL-1beta and IL-18). Upon signaling, the inflammasome complex forms around a NOD-like receptor family member that serves both as a danger sensor and as a recruiting platform. The number of known triggers that stimulate inflammasomes is rapidly rising, ranging from genetic mutations to microbial products, gout crystals, ultraviolet light and adjuvant chemicals. As a result of this surprising diversity, the inflammasome may have a significant impact on most medical fields. A good understanding of the molecular mechanisms underlying its activation/regulation is essential today, as several therapeutic and diagnostic tools have already reached the bedside, and more are sure to come.

• Authors: Olivier Gaide, Hal M Hoffman
• Journal: Expert review of clinical immunology (Expert Rev Clin Immunol) Vol. 4 Issue 1 Pg. 61-77 (Jan 2008) ISSN: 1744-8409 [Electronic] England
• PMID: 20477588 (Publication Type: Journal Article)