Modulite technology in the development of formoterol HFA pMDI: clinical evidence and future opportunities.

Abstract

This article is based on published safety and efficacy data on formoterol pressurized metered-dose inhalers (pMDIs) developed with the Modulite technology. This technology allows the development of ozone-friendly inhaled drugs that replace the same doses of chlorofluorocarbon (CFC)-formulated products and enables the attainment of new formulations with extra-fine particles and improved lung deposition. Clinical pharmacology, as well as clinical studies against comparators, have demonstrated that formoterol Modulite and the existing dry powder inhaler and CFC formoterol formulations have a similar pharmacokinetic profile, are clinically equivalent in bronchodilating effects and exhibit a similar potential for systemic side effects. Therefore, the Modulite formoterol hydrofluoroalkane-based formulation in extra-fine particles is a valuable therapeutic option for both patients and physicians in the management of asthma and chronic obstructive pulmonary disease.

• Authors: Jean Bousquet, Carmen Dell'anna
• Journal: Expert review of respiratory medicine (Expert Rev Respir Med) Vol. 2 Issue 1 Pg. 27-36 (Feb 2008) ISSN: 1747-6356 [Electronic] England
• PMID: 20477219 (Publication Type: Journal Article)