| Abstract | Only indirect evidence has been cited to document that lipopolysaccharide-mediated virulence at the bacterial level and serum antibodies to the O-specific side chain of the lipopolysaccharide molecule may prevent shigellosis. Our proposed use of the B subunit of Shiga toxin as a carrier protein is based upon evidence (even more indirect) that serum antitoxin may reduce the severity of dysentery and diarrhea. Because animal models of disease may provide information inapplicable to the prediction of vaccine-induced protective immunity, we suggest that clinical trials in the population at risk should be started after successful completion of the safety and immunogenicity phases of vaccine development in laboratory animals and in the target population. Clinical studies of shigella vaccines are difficult because of the many causes of dysentery in a population with a high rate of intestinal disease. |
| Authors | J B Robbins, C Chu, D C Watson, S C Szu, E M Daniels, C U Lowe, R Schneerson
(Affiliation: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.)
|
| Journal | Reviews of infectious diseases
(Rev Infect Dis)
1991 Mar-Apr
Vol. 13 Suppl 4
Pg. S362-5
ISSN: 0162-0886 UNITED STATES |
| PMID | 2047664
(Publication Type: Journal Article, Review)
|
| Chemical References |
- Bacterial Toxins
- Bacterial Vaccines
- Cytotoxins
- Enterotoxins
- Shiga Toxins
|
| Topics |
- Animals
- Bacterial Toxins
(immunology)
- Bacterial Vaccines
- Cytotoxins
(immunology)
- Dysentery, Bacillary
(prevention & control)
- Enterotoxins
(immunology)
- Humans
- Shiga Toxins
- Shigella
(immunology, pathogenicity)
- Virulence
|
