[An experimental research of neuroglobin expression changes and neural apoptosis after traumatic brain injury].

Abstract

OBJECTIVE:

To study the expression changes of neuroglobin in rats with the model of diffuse traumatic brain injury and explore the relationship between the neuroglobin and neuron apoptosis in traumatic brain injury.

METHODS:

The diffuse traumatic brain injury of rats was induced by the Marmarou's 'weight-drop' device. And the immunohistochemical technique was used to detect the expression changes of neuroglobin and neuron apoptosis in rat brain at different time points post-injury.

RESULTS:

The expression of neuroglobin increased twice and reached peaks at 2 hours and 72 hours post-injury respectively. And the increased expression of neuroglobin from 30 minutes to 1 hour post-injury and from 48 hours to 72 hours post-injury accompanied with the decreased expression ratio of Bax to Bcl-2.

CONCLUSION:

The increased expression of neuroglobin in traumatic brain injury informed us that neuroglobin had anti-apoptosis action in post-injury neuron. It could protect the neuron from traumatic stress and secondary ischemia and hypoxia insults during ultra-early and acute stages.

• Authors: Xin Lin, Min Li, Ya-zhuo Hu, Zhi-tao Han, Hong-hong Zhang, Ai-jia Shang, De-wei Gao, Ding-biao Zhou
• Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology (Zhongguo Ying Yong Sheng Li Xue Za Zhi) Vol. 26 Issue 1 Pg. 39-44 (Feb 2010) ISSN: 1000-6834 [Print] China
• PMID: 20476562 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nerve Tissue Proteins
• Neuroglobin
• Globins

Topics

• Animals
• Apoptosis (physiology)
• Brain (metabolism, pathology)
• Brain Injuries (metabolism, pathology)
• Globins (metabolism)
• Male
• Nerve Tissue Proteins (metabolism)
• Neuroglobin
• Neurons (pathology)
• Random Allocation
• Rats
• Rats, Sprague-Dawley