A quadrivalent HPV vaccine induces humoral and cellular immune responses in WHIM immunodeficiency syndrome.

Abstract

WHIM-syndrome is an inherited immunodeficiency disorder with abnormal susceptibility to human papillomavirus (HPV) infection and diseases. We determined safety and immunogenicity to a quadrivalent HPV vaccine in WHIM-syndrome by detection of HPV-specific antibodies and lymphoproliferation. In virus-like-particle (VLP)-ELISA, a WHIM patient showed antibody titers up to 400 for HPV-6/11/16/18, whereas immuno-competent controls developed titers of 6400-25,600. In pseudovirion assays, the patient's neutralization titers ranged from 20 to 400 to the four HPV vaccine types, while titers of 1600-25,600 were detected in healthy vaccinees. Specific proliferation of PBMC of the WHIM patient to the HPV vaccine was demonstrated. This first report on response to HPV vaccination in WHIM-immunodeficiency highlights that patients with WHIM-syndrome, and probably other immunodeficiencies, may benefit from HPV immunoprophylaxis.

• Authors: Alessandra Handisurya, Christina Schellenbacher, Bärbel Reininger, Frieder Koszik, Philipp Vyhnanek, Andreas Heitger, Reinhard Kirnbauer, Elisabeth Förster-Waldl
• Journal: Vaccine (Vaccine) Vol. 28 Issue 30 Pg. 4837-41 (Jul 05 2010) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 20472031 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
• Papillomavirus Vaccines

Topics

• Cell Proliferation
• Child
• Enzyme-Linked Immunosorbent Assay
• Female
• Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
• Humans
• Immunity, Cellular (immunology)
• Immunity, Humoral (immunology)
• Immunologic Deficiency Syndromes (congenital, genetics, immunology)
• Lymphocytes (immunology)
• Neutralization Tests
• Papillomavirus Vaccines (immunology)
• Virion (immunology)