[Multiple myeloma complicated with Takotsubo cardiomyopathy].

Abstract

A 67-year-old woman with refractory multiple myeloma was admitted to our hospital for salvage therapy. She developed fever several days after chemotherapy was initiated and complained of chest pain. Since abnormal electrocardiogram was demonstrated. Emergency coronary angiography was performed, but the coronary artery did not demonstrate stenosis. Thereafter, the patient was diagnosed as having takotsubo cardiomyopathy. Hydragogue and nitric acid preparation transiently improved chest symptoms, but high fever persisted despite antibiotic and antifungal agents. She died on the 9th day after the initiation of chemotherapy. Physicians need to be aware that cardiomyopathy may develop as a severe side effect of chemotherapy.

• Authors: Toru Mitsumori, Kei Nakajima, Yumi Nozaki, Satoshi Hamanaka, Takahiro Nagashima, Keita Kirito, Noriaki Iwao, Norio Komatsu
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 51 Issue 4 Pg. 291-6 (Apr 2010) ISSN: 0485-1439 [Print] Japan
• PMID: 20467228 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Vincristine
• Dexamethasone
• Doxorubicin
• Prednisolone
• Melphalan

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects, therapeutic use)
• Dexamethasone (administration & dosage, adverse effects)
• Doxorubicin (administration & dosage, adverse effects)
• Fatal Outcome
• Female
• Humans
• Melphalan (administration & dosage, adverse effects)
• Multiple Myeloma (complications, drug therapy)
• Prednisolone (administration & dosage, adverse effects)
• Salvage Therapy (adverse effects)
• Takotsubo Cardiomyopathy (etiology)
• Vincristine (administration & dosage, adverse effects)