Abstract | BACKGROUND: METHODS: Prepubertal (6 weeks old) and adult (10 weeks old) Dahl SS rats fed a high (8.0%) salt (HS) diet for 10 weeks were compared in terms of BP and renal function. The effect of treatment between the ages of 4 and 10 weeks with the MR antagonist eplerenone (0.125% in chow), the vasodilator hydralazine (50 mg/kg/day in drinking water) or the superoxide dismutase mimetic 4-hydroxy-2,2,6,6-tetramethyl-piperidine-N-oxyl ( tempol) (0.6 mmol/kg/day in drinking water) on the BP and renal function of prepubertal rats fed a HS diet for 10 weeks was also examined. RESULTS: CONCLUSIONS: Dahl SS rats exposed to excessive salt in prepubescence show a permanent increase in susceptibility to salt-induced hypertension and proteinuria. MR activation may promote these effects at least in part by inducing oxidation and inflammation.
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Authors | Hiroo Kawarazaki, Katsuyuki Ando, Ai Nagae, Megumi Fujita, Hiromitsu Matsui, Toshiro Fujita |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 25
Issue 9
Pg. 2879-89
(Sep 2010)
ISSN: 1460-2385 [Electronic] England |
PMID | 20466668
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Antioxidants
- Cyclic N-Oxides
- Mineralocorticoid Receptor Antagonists
- Receptors, Mineralocorticoid
- Sodium Chloride, Dietary
- Spin Labels
- Hydralazine
- Spironolactone
- Eplerenone
- 8-Hydroxy-2'-Deoxyguanosine
- Deoxyguanosine
- tempol
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Topics |
- 8-Hydroxy-2'-Deoxyguanosine
- Animals
- Antihypertensive Agents
(pharmacology)
- Antioxidants
(pharmacology)
- Blood Pressure
(drug effects)
- Cyclic N-Oxides
(pharmacology)
- Deoxyguanosine
(analogs & derivatives, metabolism)
- Eplerenone
- Hydralazine
(pharmacology)
- Hypertension
(drug therapy, etiology, metabolism)
- Kidney
(drug effects, metabolism)
- Male
- Mineralocorticoid Receptor Antagonists
(pharmacology)
- Rats
- Rats, Inbred Dahl
- Receptors, Mineralocorticoid
(metabolism)
- Renal Insufficiency
(drug therapy, etiology, metabolism)
- Sodium Chloride, Dietary
(toxicity)
- Spin Labels
- Spironolactone
(analogs & derivatives, pharmacology)
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