Abstract |
Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine improved itching (P < 0.0058) and clinical scores (P < 0.032) significantly more than topical steroids. Disease activity did not correlate with CD4+ and CD8+ T cell counts and was independent of anti-retroviral medication. Therefore, oral antihistamines are an effective first-line treatment for PPE.
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Authors | Alexander A Navarini, Marcel Stoeckle, Susanne Navarini, Erik Mossdorf, Boniphace S Jullu, Rehema Mchomvu, Marco Mbata, Patience Kibatala, Marcel Tanner, Christoph Hatz, Peter Schmid-Grendelmeier |
Journal | International journal of dermatology
(Int J Dermatol)
Vol. 49
Issue 1
Pg. 83-6
(Jan 2010)
ISSN: 1365-4632 [Electronic] England |
PMID | 20465620
(Publication Type: Journal Article)
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Chemical References |
- Histamine Antagonists
- Histamine H1 Antagonists
- Steroids
- Promethazine
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Topics |
- Administration, Oral
- Administration, Topical
- Antiretroviral Therapy, Highly Active
- CD4-CD8 Ratio
- Exanthema
(drug therapy, pathology, virology)
- HIV Infections
(complications, drug therapy, immunology)
- Histamine Antagonists
(administration & dosage)
- Histamine H1 Antagonists
(administration & dosage)
- Humans
- Promethazine
(administration & dosage)
- Pruritus
(drug therapy, pathology, virology)
- Retrospective Studies
- Steroids
(administration & dosage)
- Surveys and Questionnaires
- Tanzania
- Treatment Outcome
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