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Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption.

Abstract
Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine improved itching (P < 0.0058) and clinical scores (P < 0.032) significantly more than topical steroids. Disease activity did not correlate with CD4+ and CD8+ T cell counts and was independent of anti-retroviral medication. Therefore, oral antihistamines are an effective first-line treatment for PPE.
AuthorsAlexander A Navarini, Marcel Stoeckle, Susanne Navarini, Erik Mossdorf, Boniphace S Jullu, Rehema Mchomvu, Marco Mbata, Patience Kibatala, Marcel Tanner, Christoph Hatz, Peter Schmid-Grendelmeier
JournalInternational journal of dermatology (Int J Dermatol) Vol. 49 Issue 1 Pg. 83-6 (Jan 2010) ISSN: 1365-4632 [Electronic] England
PMID20465620 (Publication Type: Journal Article)
Chemical References
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Steroids
  • Promethazine
Topics
  • Administration, Oral
  • Administration, Topical
  • Antiretroviral Therapy, Highly Active
  • CD4-CD8 Ratio
  • Exanthema (drug therapy, pathology, virology)
  • HIV Infections (complications, drug therapy, immunology)
  • Histamine Antagonists (administration & dosage)
  • Histamine H1 Antagonists (administration & dosage)
  • Humans
  • Promethazine (administration & dosage)
  • Pruritus (drug therapy, pathology, virology)
  • Retrospective Studies
  • Steroids (administration & dosage)
  • Surveys and Questionnaires
  • Tanzania
  • Treatment Outcome

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