Abstract | PURPOSE: METHODS: Swine were divided into control group (group C), low-dose sivelestat group (group L), and high-dose sivelestat group (group H) (n = 7 for each group). All the swine were subjected to myocardial ischemia through ligation of the left anterior descending (LAD) coronary artery for 12-min, followed by 90-min reperfusion. Sivelestat was infused intracoronally at concentrations of 6 and 60 mg/ml throughout the reperfusion period in groups L and H, respectively, while saline was infused in the group C. Heart rate (HR), left ventricular developed pressure (LVdP), maximum rate of LVdP (LVdP/dt (max)), LV end-diastolic pressure (LVEDP), percentage of segment shortening (%SS, an index of regional myocardial contractility), and coronary venous interleukin-6 concentration in the LAD perfusion area were measured before ischemic induction and during reperfusion. RESULTS: The ischemia/reperfusion insult did not cause any significant changes in HR, LVdP, LVdP/dt (max), and LVEDP in all groups. However, it significantly reduced %SS in the LAD perfusion area and increased the interleukin-6 concentration in group C. Those changes in %SS and the interleukin-6 concentration were both greatly attenuated, but not prevented, in groups L and H. CONCLUSION:
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Authors | Daiji Akiyama, Tetsuya Hara, Osamu Yoshitomi, Takuji Maekawa, Sungsam Cho, Koji Sumikawa |
Journal | Journal of anesthesia
(J Anesth)
Vol. 24
Issue 4
Pg. 575-81
(Aug 2010)
ISSN: 1438-8359 [Electronic] Japan |
PMID | 20464430
(Publication Type: Journal Article)
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Chemical References |
- Interleukin-6
- Proteinase Inhibitory Proteins, Secretory
- Sulfonamides
- sivelestat
- Glycine
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Topics |
- Animals
- Coronary Circulation
(drug effects)
- Female
- Glycine
(analogs & derivatives, therapeutic use)
- Interleukin-6
(biosynthesis)
- Male
- Myocardial Ischemia
(drug therapy)
- Myocardial Stunning
(prevention & control)
- Proteinase Inhibitory Proteins, Secretory
(therapeutic use)
- Sulfonamides
(therapeutic use)
- Swine
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