Efficacy of an alpha-hydroxy acid (AHA)-based cream, even in monotherapy, in patients with mild-moderate acne.

Abstract

AIM AND METHODS:

The treatment of mild-moderate acne with topical drugs in association with appropriate cosmetics is currently the golden standard. The tolerability and efficacy of a cream formulated with a new mix of alpha-hydroxy acids (Hyseac AHA cream) in 248 patients with mild-moderate acne (comedonic, inflammatory, or mixed) have been investigated in a multicenter, non-randomized, open study by 10 dermatologists from different Italian areas during their routine practice. The medication with Hyseac AHA cream was prescribed at first consultation for 60 days, twice a day, either as a monotherapy (49.2% patients) or in association with a pharmacological treatment (50.2%).

RESULTS:

The tolerability was good to excellent in 92.3% patients, without significant differences between patients using AHA cream in monotherapy (90.0%) or associated with concomitant pharmacological treatment (97.6%). The efficacy was overall high in 64.2% patients, again without significant differences related to concomitant pharmacological treatment or not (64.8% vs. 63.3%) and/or the acne clinical type (comedonic vs. inflammatory vs. mixed: 69.2% vs. 66.7% vs. 58%).

CONCLUSION:

The results of this study, while confirming the high tolerability and efficacy of this AHA cream in the treatment of mild/moderate acne, reasonably suggest its possible use also in monotherapy. Furthermore, its use can be reasonably hypothesized as a maintenance treatment after specific pharmacological treatment even in more severe acne types.

• Authors: A Baldo, P Bezzola, S Curatolo, T Florio, G Lo Guzzo, M Lo Presti, G P Sala, F Serra, E Tonin, M Pellicano, N Pimpinelli
• Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia (G Ital Dermatol Venereol) Vol. 145 Issue 3 Pg. 319-22 (Jun 2010) ISSN: 0392-0488 [Print] Italy
• PMID: 20461041 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Hydroxy Acids

Topics

• Acne Vulgaris (drug therapy)
• Adolescent
• Adult
• Child
• Female
• Humans
• Hydroxy Acids (therapeutic use)
• Male
• Middle Aged
• Severity of Illness Index
• Young Adult