Papuabalanols A and B, new tannins from Balanophora papuana.

Abstract

Two new dehydrohexahydroxydiphenoyl (DHHDP) esters of dihydrochalcone glycosides, papuabalanols A (1) and B (2) were isolated from the ethyl acetate extract of Balanophora papuana. Their structures were elucidated on the basis of spectroscopic data and chemical evidences. Papuabalanol A (1) showed moderate vasodilator effect on rat aorta and papuabalanol B (2) showed potent inhibition of mushroom tyrosinase and anti-melanogenesis in B16 mouse melanoma cells.

• Authors: Takahiro Hosoya, Asami Nakata, Kazumasa Zaima, Jalifah Latip, Laily Bin Din, Noramly Muslim, Hiroshi Morita
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 58 Issue 5 Pg. 738-41 (May 2010) ISSN: 1347-5223 [Electronic] Japan
• PMID: 20460807 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Enzyme Inhibitors
• Plant Extracts
• Tannins
• Vasodilator Agents
• papuabalanol A
• papuabalanol B

Topics

• Animals
• Balanophoraceae (chemistry)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Enzyme Inhibitors (chemistry, isolation & purification, pharmacology)
• Magnetic Resonance Spectroscopy
• Mice
• Molecular Structure
• Plant Components, Aerial (chemistry)
• Plant Extracts (pharmacology)
• Rats
• Tannins (chemistry, isolation & purification, therapeutic use)
• Vasodilator Agents (chemistry, isolation & purification, pharmacology)