Evaluation of flavoglaucin, its derivatives and pyranonigrins produced by molds used in fermented foods for inhibiting tumor promotion.

Abstract

Flavoglaucin, its derivatives, and pyranonigrins, which are antioxidants produced by the molds used in fermented foods, were examined for their inhibition of tumor promotion by the Epstein-Barr virus early antigen activation test. Flavoglaucin and its derivatives exhibited high activity. Flavoglaucin and such a derivative as isodihydroauroglaucin inhibited mouse skin tumor promotion in a two-stage carcinogenesis test and appear to be antitumor promoters.

• Authors: Yoshiaki Miyake, Chihiro Ito, Harukuni Tokuda, Toshihiko Osawa, Masataka Itoigawa
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 74 Issue 5 Pg. 1120-2 ( 2010) ISSN: 1347-6947 [Electronic] England
• PMID: 20460698 (Publication Type: Journal Article)

Chemical References

• Antigens, Viral
• Antioxidants
• Gentisates
• Pyrones
• flavoglaucin

Topics

• Animals
• Antigens, Viral (immunology)
• Antioxidants (chemistry, isolation & purification, metabolism, pharmacology)
• Cell Line, Tumor
• Fermentation
• Food Microbiology
• Fungi (metabolism)
• Gentisates (chemistry, isolation & purification, metabolism, pharmacology)
• Herpesvirus 4, Human (drug effects, immunology)
• Humans
• Inhibitory Concentration 50
• Mice
• Pyrones (metabolism, pharmacology)
• Skin Neoplasms (pathology, virology)