Peripheral arthritis in the course of inflammatory bowel diseases.

Abstract

BACKGROUND:

Musculoskeletal disorders are well-defined extra-intestinal manifestations of inflammatory bowel diseases (IBD). There is little data regarding the frequencies of IBD and extra-intestinal manifestations from Central and East Europe and Middle Eastern countries.

AIMS:

To determine the prevalence of peripheral arthritis in IBD and to document the relationship to other extra-intestinal manifestations.

METHODS:

Enrolled in the study were 357 patients who were diagnosed with IBD from December 2002 through January 2008. All of the patients underwent a detailed whole-body examination by a gastroenterologist and rheumatologist.

RESULTS:

IBD-related peripheral arthritis (IBDPA) was found in 66 (18.5%) of the 357 patients (28.3% Crohn's disease, 13.5% ulcerative colitis; p=0.001 χ=11.62). IBDPA was more frequent in female patients (60.6 vs. 39.4%, p=0.000, χ=11.12). In eight (12.1%) cases, IBDPA occurred before the onset of IBD. Acute self-limiting episodes, recurrences of the attacks, and persistent symptoms of arthritis were present in 40 (60.6%), 26 (39.3%), and 29 (45.7%) patients, respectively. Arthritis was symmetrical in 33 (50%) cases. Knees (65.2%) and ankles (62.1%) were the most commonly affected joints. Erythema nodosum and pyoderma gangrenosum were more common among patients with IBDPA than patients without it (p=0.001, χ=10.49, and p=0.000 χ=25.77, respectively).

CONCLUSIONS:

IBDPA is a frequent extra-intestinal complication of IBD. Those of female gender and the presence of Crohn's disease, erythema nodosum and pyoderma gangrenosum have a higher risk to develop IBDPA.

• Authors: Ilhami Yüksel, Hilmi Ataseven, Omer Başar, Seyfettin Köklü, Ibrahim Ertuğrul, Aysel Ulker, Ulkü Dağlı, Nurgül Saşmaz
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 56 Issue 1 Pg. 183-7 (Jan 2011) ISSN: 1573-2568 [Electronic] United States
• PMID: 20458624 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Ankle Joint
• Arthritis (epidemiology)
• Child
• Colitis, Ulcerative (complications, epidemiology)
• Crohn Disease (complications, epidemiology)
• Erythema Nodosum (complications, epidemiology)
• Europe (epidemiology)
• Female
• Humans
• Knee Joint
• Male
• Middle Aged
• Middle East (epidemiology)
• Prevalence
• Pyoderma Gangrenosum (complications, epidemiology)
• Retrospective Studies
• Risk Factors
• Sex Factors
• Young Adult