Antihyperlipidemic effect of flavonoids from Prunus davidiana.

Blood lipid levels in rats with hyperlipidemia resulting from high-fat feeding were determined after ip administration of an MeOH extract of Prunus davidiana stems and its flavonoid components, (+)-catechin, prunin (= naringenin 7-O-glucoside), and hesperetin 5-O-glucoside. Administration of the MeOH extract for 3 days produced a significant decrease of blood triglyceride and total cholesterol, and the atherogenic index was also improved. (+)-Catechin was shown to be effective in reducing the elevated level of triglyceride. Prunin and hesperetin 5-O-glucoside did not show such an effect in high-fat-fed hypertriglyceridemic rats, but they did exhibit a significant hypocholesterolemic effect.
AuthorsJ S Choi, T Yokozawa, H Oura
JournalJournal of natural products (J Nat Prod) 1991 Jan-Feb Vol. 54 Issue 1 Pg. 218-24 ISSN: 0163-3864 [Print] UNITED STATES
PMID2045817 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Flavonoids
  • Globulins
  • Lipids
  • Plant Proteins
  • prunin protein, Prunus
  • hesperetin 5-O-glucoside
  • Catechin
  • Hesperidin
  • Animals
  • Catechin (pharmacology)
  • Flavonoids (isolation & purification, pharmacology)
  • Globulins
  • Hesperidin (analogs & derivatives)
  • Hyperlipidemias (drug therapy)
  • Lipids (blood)
  • Male
  • Molecular Structure
  • Plant Proteins
  • Plants (analysis)
  • Rats
  • Rats, Inbred Strains

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