Antihyperlipidemic effect of flavonoids from Prunus davidiana.

Abstract

Blood lipid levels in rats with hyperlipidemia resulting from high-fat feeding were determined after ip administration of an MeOH extract of Prunus davidiana stems and its flavonoid components, (+)-catechin, prunin (= naringenin 7-O-glucoside), and hesperetin 5-O-glucoside. Administration of the MeOH extract for 3 days produced a significant decrease of blood triglyceride and total cholesterol, and the atherogenic index was also improved. (+)-Catechin was shown to be effective in reducing the elevated level of triglyceride. Prunin and hesperetin 5-O-glucoside did not show such an effect in high-fat-fed hypertriglyceridemic rats, but they did exhibit a significant hypocholesterolemic effect.

• Authors: J S Choi, T Yokozawa, H Oura
• Journal: Journal of natural products (J Nat Prod) 1991 Jan-Feb Vol. 54 Issue 1 Pg. 218-24 ISSN: 0163-3864 [Print] United States
• PMID: 2045817 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Flavonoids
• Globulins
• Lipids
• Plant Proteins
• prunin protein, Prunus
• hesperetin 5-O-glucoside
• Catechin
• Hesperidin

Topics

• Animals
• Catechin (pharmacology)
• Flavonoids (isolation & purification, pharmacology)
• Globulins
• Hesperidin (analogs & derivatives)
• Hyperlipidemias (drug therapy)
• Lipids (blood)
• Male
• Molecular Structure
• Plant Proteins
• Plants (analysis)
• Rats
• Rats, Inbred Strains