Abstract | INTRODUCTION: METHODS: Forty patients were randomized to either LOLA or a placebo. HE was evaluated by psychometric testing (PSE Syndrome Test) and critical flicker frequency (CFF). Posturography [equilibrium score (ES)] provided information regarding postural control. Peripheral blood was analysed for ammonia concentration (NH(3)) and the partial pressure of ammonia (pNH(3)). RESULTS: Both groups were comparable regarding baseline variables. Posturography and PSE Syndrome Test improved in both groups; improvement was greater in the LOLA group (ES: 5.3%; PSE: 1.9) compared with the placebo (ES: 3.9%; PSE: 1.3) but did not reach significance (ES: P=0.3; PSE: P=0.5). CFF remained unchanged during treatment and between groups (P=NS). NH(3) decreased in the LOLA group (Delta: -15 micromol/L) and slightly increased in the placebo group (Delta: 11.1 micromol/L), but the differences did not reach statistical significance (P=0.07). pNH(3) remained largely unchanged (LOLA Delta: -1.2 x 10(-5) mmHg vs. placebo Delta: -0.3 x 10(-5) mmHg; P=0.21). CONCLUSION: In the LOLA group, an improvement of posturographic control and PSE Syndrome Test was observed, but a similar improvement was also achieved by the placebo. In LOLA, ammonia levels tended to decrease while they tended to increase in the placebo group. LOLA might augment the improvement achieved by intravenous fluids alone but a larger cohort will be needed to show this effect with statistical significance.
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Authors | Monika Schmid, Markus Peck-Radosavljevic, Franz König, Christian Mittermaier, Alfred Gangl, Peter Ferenci |
Journal | Liver international : official journal of the International Association for the Study of the Liver
(Liver Int)
Vol. 30
Issue 4
Pg. 574-82
(Apr 2010)
ISSN: 1478-3231 [Electronic] United States |
PMID | 20456040
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Dipeptides
- Ammonia
- ornithylaspartate
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Topics |
- Aged
- Ammonia
(blood)
- Biopsy, Needle
- Dipeptides
(administration & dosage)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Administration Schedule
- Female
- Follow-Up Studies
- Hepatic Encephalopathy
(complications, drug therapy, mortality, pathology, psychology)
- Humans
- Immunohistochemistry
- Infusions, Intravenous
- Liver Cirrhosis
(complications, drug therapy, mortality, pathology)
- Liver Function Tests
- Male
- Middle Aged
- Pilot Projects
- Postural Balance
(drug effects)
- Psychometrics
- Reference Values
- Risk Assessment
- Sensation Disorders
(drug therapy, etiology)
- Severity of Illness Index
- Statistics, Nonparametric
- Survival Rate
- Treatment Outcome
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