Abstract | BACKGROUND: METHODS: Females aged 15 to 35 years reporting sexual contact to a male partner diagnosed with N. gonorrhoeae were enrolled. Demographic and sexual histories, physical findings, and laboratory tests were collected. Women testing positive and negative for cervical N. gonorrhoeae were compared using chi and Fisher exact tests, with multivariable logistic regression performed on those factors independently associated with gonococcal infection on univariate analysis. RESULTS: N. gonorrhoeae infection occurred in 68 of 107 (64%) women. Women using combined hormonal contraception were significantly less likely than nonusers to test positive for N. gonorrhoeae (32% vs. 76%; prevalence ratio: 0.42; 95% confidence interval: 0.22, 0.78; P = 0.006). Gonorrhea was also less common in depomedroxyprogesterone acetate users. A new sexual partner was also associated with testing positive for gonorrhea (35% vs. 13%; prevalence ratio: 1.47; 95% confidence interval: 1.13, 1.90; P = 0.004). CONCLUSIONS: Women using combined hormonal contraceptives or depomedroxyprogesterone acetate were less likely to test positive for N. gonorrhoeae after sexual exposure compared with nonusers. Our data suggest that, in addition to contraceptive benefits, modern hormonal contraception may have a protective effect on the acquisition of N. gonorrhoeae.
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Authors | Priya R Gursahaney, Leslie A Meyn, Sharon L Hillier, Richard L Sweet, Harold C Wiesenfeld |
Journal | Sexually transmitted diseases
(Sex Transm Dis)
Vol. 37
Issue 6
Pg. 356-60
(Jun 2010)
ISSN: 1537-4521 [Electronic] United States |
PMID | 20453722
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Contraceptive Agents, Female
- Contraceptives, Oral, Hormonal
- Medroxyprogesterone Acetate
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Topics |
- Adolescent
- Adult
- Contraceptive Agents, Female
(administration & dosage)
- Contraceptives, Oral, Hormonal
(administration & dosage)
- Female
- Gonorrhea
(epidemiology, microbiology, prevention & control, transmission)
- Humans
- Interviews as Topic
- Longitudinal Studies
- Male
- Medroxyprogesterone Acetate
(administration & dosage)
- Neisseria gonorrhoeae
- Sexual Behavior
- Treatment Outcome
- Urethritis
(epidemiology, microbiology, prevention & control)
- Uterine Cervicitis
(microbiology, prevention & control)
- Young Adult
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