Abstract | OBJECTIVE: The objective of the study was to determine the frequency and clinical significance of intraamniotic inflammation in asymptomatic women with a sonographic short cervix (SCX) in the midtrimester. STUDY DESIGN: This cohort study included 47 asymptomatic women (14-24 weeks) with an SCX (<or=15 mm) who underwent amniocentesis. Women with multiple gestation, cerclage, or cervical dilatation greater than 2 cm were excluded. Intraamniotic inflammation was defined as an elevated amniotic fluid (AF) matrix metalloproteinase-8 concentration (>23 ng/mL). RESULTS: (1) intraamniotic infection was found in 4.3% of patients; (2) among patients with a negative AF culture, the prevalence of intraamniotic inflammation was 22.2%; and (3) patients with a negative AF culture, but with intraamniotic inflammation, had a higher rate of delivery within 7 days (40% vs 5.7%; P=.016) and a shorter median diagnosis-to-delivery interval than those without intraamniotic inflammation (18 vs 42 days; P=.01). CONCLUSION: Twenty-two percent of patients with a midtrimester SCX have intraamniotic inflammation. The risk of preterm delivery within 7 days for these patients is 40%.
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Authors | Edi Vaisbuch, Sonia S Hassan, Shali Mazaki-Tovi, Chia-Ling Nhan-Chang, Juan Pedro Kusanovic, Tinnakorn Chaiworapongsa, Zhong Dong, Lami Yeo, Pooja Mittal, Bo Hyun Yoon, Roberto Romero |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 202
Issue 5
Pg. 433.e1-8
(May 2010)
ISSN: 1097-6868 [Electronic] United States |
PMID | 20452483
(Publication Type: Journal Article, Research Support, N.I.H., Intramural)
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Chemical References |
- Matrix Metalloproteinase 8
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Topics |
- Adult
- Cervix Uteri
(anatomy & histology, diagnostic imaging)
- Chorioamnionitis
(epidemiology)
- Counseling
- Female
- Humans
- Logistic Models
- Matrix Metalloproteinase 8
(blood)
- Obstetric Labor, Premature
(epidemiology)
- Pregnancy
- Pregnancy Trimester, Second
- Retrospective Studies
- Ultrasonography
- Young Adult
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