Cardioprotective effects of erythropoietin on postresuscitation myocardial dysfunction in appropriate therapeutic windows.

Abstract

OBJECTIVE:

Erythropoietin has been noted for its cardioprotective effects. The objective of the study is to investigate its effects on postresuscitation myocardial dysfunction and therapeutic windows.

DESIGN:

Randomized animal study.

SETTING:

Animal research laboratory.

SUBJECTS:

Adult male adult Wistar rats.

INTERVENTIONS:

Cardiopulmonary resuscitation was started after 6.5 or 9.5 mins of asphyxia-induced cardiac arrest. The resuscitated animals received either erythropoietin (1000, 3000, or 5000 U/kg) or placebo intravenously 3 mins after return of spontaneous circulation.

MEASUREMENTS AND MAIN RESULTS:

Erythropoietin treatment improved the 3-day survival and left ventricular dP/dt40 and peak negative dP/dt after 6.5 mins asphyxia-induced cardiac arrest. The cardioprotective effects of erythropoietin decreased after 9.5 mins asphyxia-induced cardiac arrest with worse postresuscitation left ventricular dP/dt40 and peak negative dP/dt (p < .01 for both). The erythropoietin showed a dose-dependent response for its cardioprotective effects. The 3-day survival rates were higher in the group treated with erythropoietin 5000 U/kg than with 3000 and 1000 U/kg groups (p = .045 and .003, respectively). Postresuscitation left ventricular dP/dt40 and peak negative dP/dt were more preserved in the group treated with erythropoietin 5000 U/kg than the groups with lower doses (p < .05 for both).

CONCLUSIONS:

Erythropoietin has the potential to improve postresuscitation myocardial dysfunction and short-term survival in appropriate therapeutic windows.

• Authors: Chien-Hua Huang, Chiung-Yuan Hsu, Min-Shan Tsai, Tzung-Dau Wang, Wei-Tien Chang, Wen-Jone Chen
• Journal: Critical care medicine (Crit Care Med) Vol. 36 Issue 11 Suppl Pg. S467-73 (Nov 2008) ISSN: 1530-0293 [Electronic] United States
• PMID: 20449912 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cardiotonic Agents
• Erythropoietin

Topics

• Animals
• Cardiotonic Agents (administration & dosage, therapeutic use)
• Coronary Circulation (drug effects)
• Dose-Response Relationship, Drug
• Erythropoietin (administration & dosage, therapeutic use)
• Heart Arrest (complications, drug therapy, physiopathology)
• Hemodynamics (drug effects)
• Male
• Myocardial Reperfusion Injury (etiology, physiopathology, prevention & control)
• Random Allocation
• Rats
• Rats, Wistar
• Respiration, Artificial
• Time Factors