G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese.

Abstract

Genetic variations in preeclampsia (PE) may affect PE risk. The G protein-coupled receptor kinase 4 (GRK4) gene encodes a member of the Ser/Thr protein kinase family and has been linked to both genetic and acquired hypertension. The aim of this study was to investigate the association between polymorphisms (T-rs1024323-C and T-rs1801058-C) in GRK4 and PE in Northern Han Chinese. Using a case-control design, the association between the GRK4 exon-4 T-rs1024323-C and exon-13 T-rs1801058-C polymorphisms and the risk of PE in Northern Han Chinese was assessed in 105 individuals with PE and 103 age- and area-matched normotensive controls. Genotypes were determined by allelic discrimination. The odds ratio and 95% confidence interval were estimated by binary logistic regression. No association was found between the GRK4 polymorphisms (T-rs1024323-C and T-rs1801058-C) and PE, and there was also no relationship with the severity of PE. The risk of homozygous and heterozygous variant allele carriers of the analyzed single-nucleotide polymorphisms did not differ significantly from that of the homozygous wild-type allele carriers, even after adjustment for age, body mass index, (family) history of hypertension and smoking status. The GRK4 (T-rs1024323-C and T-rs1801058-C) polymorphisms were not associated with a risk of PE in the present Northern Han Chinese study group. Thus, the GRK4 polymorphisms do not seem to have an important role in PE in this population.

• Authors: Cheng-Juan Sun, Wei-Yuan Zhang
• Journal: Hypertension research : official journal of the Japanese Society of Hypertension (Hypertens Res) Vol. 33 Issue 7 Pg. 683-7 (Jul 2010) ISSN: 1348-4214 [Electronic] England
• PMID: 20448640 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• G-Protein-Coupled Receptor Kinase 4

Topics

• Adult
• Asian People (genetics)
• Case-Control Studies
• Exons (genetics)
• Female
• G-Protein-Coupled Receptor Kinase 4 (genetics)
• Genetic Predisposition to Disease
• Humans
• Polymorphism, Single Nucleotide
• Pre-Eclampsia (genetics)
• Pregnancy