Abstract |
H(2)S, the most recently discovered gasotransmitter, might in fact be the evolutionary matriarch of this family, being both ancient and highly reduced. Disruption of gamma-cystathionase in mice leads to cardiovascular dysfunction and marked hypertension, suggesting a key role for this enzyme in H(2)S production in the vasculature. However, patients with inherited deficiency in gamma-cystathionase apparently do not present vascular pathology. A mitochondrial pathway disposes sulfide and couples it to oxidative phosphorylation while also exposing cytochrome c oxidase to this metabolic poison. This report focuses on the biochemistry of H(2)S biogenesis and clearance, on the molecular mechanisms of its action, and on its varied biological effects.
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Authors | Omer Kabil, Ruma Banerjee |
Journal | The Journal of biological chemistry
(J Biol Chem)
Vol. 285
Issue 29
Pg. 21903-7
(Jul 16 2010)
ISSN: 1083-351X [Electronic] United States |
PMID | 20448039
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
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Topics |
- Animals
- Humans
- Hydrogen Sulfide
(chemistry, metabolism)
- Mice
- Oxidation-Reduction
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