Natriuretic peptides in common valvular heart disease.

Abstract

Valvular heart disease, particularly aortic stenosis and mitral regurgitation, accounts for a large proportion of cardiology practice, and their prevalence is predicted to increase. Management of the asymptomatic patient remains controversial. Biomarkers have been shown to have utility in the management of cardiovascular disease such as heart failure and acute coronary syndromes. In this state-of-the-art review, we examine the current evidence relating to natriuretic peptides as potential biomarkers in aortic stenosis and mitral regurgitation. The natriuretic peptides correlate with measures of disease severity and symptomatic status and also can be used to predict outcome. This review shows that natriuretic peptides have much promise as biomarkers in common valvular heart disease, but the impact of their measurement on clinical practice and outcomes needs to be further assessed in prospective studies before routine clinical use becomes a reality.

• Authors: Christopher D Steadman, Simon Ray, Leong L Ng, Gerry P McCann
• Journal: Journal of the American College of Cardiology (J Am Coll Cardiol) Vol. 55 Issue 19 Pg. 2034-48 (May 11 2010) ISSN: 1558-3597 [Electronic] United States
• PMID: 20447526 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Natriuretic Peptides

Topics

• Aortic Valve Stenosis (diagnosis, etiology, metabolism)
• Biomarkers (metabolism)
• Humans
• Mitral Valve Insufficiency (diagnosis, etiology, metabolism)
• Natriuretic Peptides (physiology)
• Predictive Value of Tests
• Prognosis
• Severity of Illness Index