Evidence for natriuretic peptides A and B as non-invasive markers in congenital and valvular heart disease.

Abstract

AIM:

The aim of this study was to evaluate the diagnostic utility of natriuretic peptides of type A and B as noninvasive markers in the diagnosis and treatment of congenital and valvular heart disease.

METHODS:

Blood samples from 82 patients with various congenital and valvular heart diseases were measured for A and B natriuretic peptide levels and levels compared with those in a reference group of blood donors. Electrochemiluminiscence immunoassay and immunoluminometric essay were used for quantification of natriuretic peptides A and B. Particular reference values in serum or plasma of blood donors were adapted from literature.

RESULTS:

Natriuretic peptide levels in cardiac patients were significantly higher than reference levels. The levels of both peptides in blood serum or plasma showed positive correlation with age, gender and disease severity.

CONCLUSIONS:

Natriuretic peptides are efficient, non-invasive cardiac markers for facilitating diagnosis, management and treatment of valvular heart disease.

• Authors: Karel Kotaska, Richard Prusa
• Journal: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia (Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub) Vol. 154 Issue 1 Pg. 21-4 (Mar 2010) ISSN: 1804-7521 [Electronic] Czech Republic
• PMID: 20445707 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Natriuretic Peptide, Brain
• Atrial Natriuretic Factor

Topics

• Adult
• Aged
• Atrial Natriuretic Factor (blood)
• Biomarkers (blood)
• Female
• Heart Defects, Congenital (blood, diagnosis)
• Heart Valve Diseases (blood, diagnosis)
• Humans
• Male
• Middle Aged
• Natriuretic Peptide, Brain (blood)
• Young Adult