Distinct profiles of antibodies to Kaposi sarcoma-associated herpesvirus antigens in patients with Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma.

Abstract

Antibody responses against lytic and latent Kaposi sarcoma (KS)-associated herpesvirus antigens were investigated in patients with KS, multicentric Castleman disease (MCD), and primary effusion lymphoma. Antibodies against the lytic antigen K8.1 were 5-fold higher in patients with MCD than those with KS, whereas antibodies to the sum of latent antigens v-cyclin and LANA were 27-fold higher in patients with KS, compared with patients with MCD (P < 001). The sum of anti-v-cyclin and anti-LANA antibody titers discriminated patients with KS from those with MCD and KS with 93% sensitivity and 83% specificity. These results suggest that antibody responses to lytic and latent KS-associated herpesvirus antigens differ in these diseases.

• Authors: Peter D Burbelo, Alexandra T Issa, Kathryn H Ching, Kathleen M Wyvill, Richard F Little, Michael J Iadarola, Joseph A Kovacs, Robert Yarchoan
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 201 Issue 12 Pg. 1919-22 (Jun 15 2010) ISSN: 1537-6613 [Electronic] United States
• PMID: 20443737 (Publication Type: Evaluation Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral
• Antigens, Viral

Topics

• Antibodies, Viral (blood)
• Antigens, Viral (immunology)
• Castleman Disease (diagnosis, immunology)
• Herpesvirus 8, Human (immunology)
• Humans
• Lymphoma, Primary Effusion (diagnosis, immunology)
• Sarcoma, Kaposi (diagnosis, immunology)
• Sensitivity and Specificity
• Serologic Tests (methods)
• Virology (methods)