Abstract | BACKGROUND: DESIGN AND METHODS: A retrospective analysis was undertaken of the European Group for Blood and Marrow Transplantation experience of 272 patients with plasma cell leukemia and 20844 with multiple myeloma undergoing first autologous transplantation between 1980 and 2006. All patients were reported to the European Group for Blood and Marrow Transplantation registry using MED-A (limited data) or MED-B (extensive data) forms. All patients were included regardless of availability of complete data. RESULTS: There was no difference in type of graft or use of total body irradiation between patients with plasma cell leukemia and multiple myeloma, but the group with plasma cell leukemia was transplanted earlier after diagnosis (6.0 versus 7.7 months, P=0.000). Patients with plasma cell leukemia were more likely to enter complete remission after transplantation but their overall survival (25.7 months, 95% confidence interval 19.5-31.9 months) was inferior to that of patients with multiple myeloma (62.3 months, 95% confidence interval 60.4-64.3 months) (P=0.000), due to the short duration of their post-transplant response and increased non-relapse-related mortality. CONCLUSIONS:
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Authors | Mary B Drake, Simona Iacobelli, Anja van Biezen, Curly Morris, Jane F Apperley, Dietger Niederwieser, Bo Björkstrand, Gösta Gahrton, European Group for Blood and Marrow Transplantation and the European Leukemia Net |
Journal | Haematologica
(Haematologica)
Vol. 95
Issue 5
Pg. 804-9
(May 2010)
ISSN: 1592-8721 [Electronic] Italy |
PMID | 20442444
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Female
- Follow-Up Studies
- Hematopoietic Stem Cell Transplantation
(methods)
- Humans
- Leukemia, Plasma Cell
(mortality, pathology, surgery)
- Male
- Middle Aged
- Multiple Myeloma
(mortality, pathology, surgery)
- Retrospective Studies
- Survival Rate
(trends)
- Transplantation Conditioning
- Transplantation, Autologous
- Treatment Outcome
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