Abstract |
Although varicella vaccine is given to clinically stable human immunodeficiency virus (HIV)-infected children, its effectiveness is unknown. We assessed its effectiveness by reviewing the medical records of closely monitored HIV-infected children, including those receiving highly active antiretroviral therapy ( HAART) between 1989 and 2007. Varicella immunization and development of varicella or herpes zoster were noted. Effectiveness was calculated by subtracting from 1 the rate ratios for the incidence rates of varicella or herpes zoster in vaccinated versus unvaccinated children. The effectiveness of the vaccine was 82% (95% confidence interval [CI], 24%-99%; P = .01) against varicella and was 100% (95% CI, 67%-100%; P < .001) against herpes zoster. When the analysis was controlled for receipt of HAART, vaccination remained highly protective against herpes zoster.
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Authors | Moeun Son, Eugene D Shapiro, Philip LaRussa, Natalie Neu, David E Michalik, Michelle Meglin, Andrea Jurgrau, Wally Bitar, Marietta Vasquez, Patricia Flynn, Anne A Gershon |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 201
Issue 12
Pg. 1806-10
(Jun 15 2010)
ISSN: 1537-6613 [Electronic] United States |
PMID | 20441519
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-HIV Agents
- Chickenpox Vaccine
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Topics |
- Anti-HIV Agents
(therapeutic use)
- Antiretroviral Therapy, Highly Active
- Chickenpox
(epidemiology, prevention & control)
- Chickenpox Vaccine
(immunology)
- Child
- Child, Preschool
- Female
- HIV Infections
(drug therapy, immunology)
- Herpes Zoster
(epidemiology, prevention & control)
- Humans
- Male
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