Abstract | BACKGROUND: METHODS: A 22-year-old suffered severe TBI with occlusive left carotid dissection. Her course was complicated by left hemispheric infarcts with cerebral edema and intermittently elevated ICP. Conivaptan 20-mg IV was given as a bolus when serum sodium rapidly dropped to 128 mEq/l. RESULTS: This dose resulted in significant aquaresis, with over 1 l per hour of dilute urine peaking at 3-5 h after the dose. By 8 h, sodium had risen to 146 mEq/l. ICP had been stable at 11-15 mmHg for several hours prior to the dose, remained in this range for 2 h after, but then fell to 2 mmHg at 4 h, and remained reduced out to 8 h. Cerebral perfusion pressure, initially stable at 60-80 mmHg, rose to over 90 mmHg at 4 h. CONCLUSIONS:
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Authors | Rajat Dhar, Theresa Murphy-Human |
Journal | Neurocritical care
(Neurocrit Care)
Vol. 14
Issue 1
Pg. 97-102
(Feb 2011)
ISSN: 1556-0961 [Electronic] United States |
PMID | 20440600
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antidiuretic Hormone Receptor Antagonists
- Benzazepines
- conivaptan
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Topics |
- Antidiuretic Hormone Receptor Antagonists
- Benzazepines
(administration & dosage)
- Brain Injuries
(complications, diagnostic imaging)
- Cerebral Angiography
- Female
- Humans
- Hyponatremia
(drug therapy, etiology)
- Intracranial Hypertension
(drug therapy, etiology)
- Tomography, X-Ray Computed
- Young Adult
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