| Abstract | Leukemic cells from 51 pediatric patients (younger than 18 years) diagnosed with acute lymphoid leukemia by standard morphologic and cytochemical methods were subjected to flow cytometric studies using a panel of monoclonal antibodies against T-cell (CD1, 2, 3, 4, 5, 7, 8), B-cell (CD10, 19, 20, 21), myeloid (CD13, 14, 15, 33), and HLA-DR antigens. Cases of "conventional" acute lymphoid leukemia (leukemic cells with a normal configuration of B-cell or T-cell differentiation antigens) were observed in 26 of 51 (51%) cases, whereas cases of "aberrant" acute lymphoid leukemia (cells with abnormal patterns of B-cell or T-cell antigens or with concomitant myeloid antigens) were noticed in 25 (49%) cases. Myeloid antigen-positive acute lymphoid leukemia was observed in the leukemic cells of eight (16%) individuals. No significant differences were observed between conventional and aberrant ALL in the distribution of sex, age, leukocyte count, hemoglobin concentration, platelet count, blast count, French-American-British (FAB) type, lymphadenopathy, organomegaly, rate or duration of remission, or survival. When only myeloid antigen-positive cases were compared with myeloid antigen negative-cases, no significant correlations were observed except for duration of first remission (myeloid antigen positive, 26+ +/- 22 months; myeloid antigen negative, 40+ +/- 18 months; P less than 0.001), and duration of survival (myeloid antigen positive, 27+ +/- 24 months; myeloid antigen negative, 62+ +/- 17 months; P = 0.001). These data suggest that pediatric patients with ALL blasts possessing myeloid antigens may represent a high-risk group for length of remission and survival. |
| Authors | A S Kurec, P Belair, C Stefanu, D M Barrett, R L Dubowy, F R Davey
(Affiliation: Department of Pathology, SUNY Health Science Center, Syracuse.)
|
| Journal | Cancer
(Cancer)
Vol. 67
Issue 12
Pg. 3081-6
(Jun 15 1991)
ISSN: 0008-543X UNITED STATES |
| PMID | 2044051
(Publication Type: Journal Article)
|
| Chemical References |
- Antibodies, Monoclonal
- Antigens, Differentiation, B-Lymphocyte
- Antigens, Differentiation, Myelomonocytic
- Antigens, Differentiation, T-Lymphocyte
|
| Topics |
- Adolescent
- Antibodies, Monoclonal
- Antigens, Differentiation, B-Lymphocyte
(analysis)
- Antigens, Differentiation, Myelomonocytic
(analysis)
- Antigens, Differentiation, T-Lymphocyte
(analysis)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- B-Lymphocyte Subsets
(immunology, pathology)
- Burkitt Lymphoma
(pathology)
- Child
- Child, Preschool
- Female
- Flow Cytometry
- Humans
- Immunophenotyping
- Infant
- Leukemia-Lymphoma, Adult T-Cell
(pathology)
- Male
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(drug therapy, pathology)
- Prognosis
- Remission Induction
- T-Lymphocyte Subsets
(immunology, pathology)
|
