Abstract |
The outcome of stent implantation for pulmonary vein stenosis (PVS) in children remains poor. Several reports describe placing drug-eluting stents to treat PVS, but their effectiveness remains unknown. In this study, three bare- metal stents (BMSs) and three sirolimus-eluting stents (SESs) were implanted in 1-month-old pigs. The pigs were killed 8 weeks later to compare in- stent stenosis rates. The extent of neointimal thickness, as measured by injury score, was significantly less in the SES group than in the BMS group (injury score 1: BMS 0.351 + or - 0.033 vs SES 0.226 + or - 0.031 mm; P < 0.01; injury score 2: BMS 1.232 + or - 0.244 vs SES 0.609 + or - 0.208 mm; P < 0.01). The pathologic findings showed confluence of inflammatory cells around the stent wires in BMS-treated areas and granuloma formation. Granuloma formation was not seen with SES. The degree of in- stent stenosis was significantly reduced in the SES group, suggesting that the use of drug-eluting stents is an effective treatment for PVS. Because of the small sample size and the considerable variation in injury scores and balloon-to-vein ratios, future studies with larger samples are necessary.
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Authors | Takeshi Furukawa, Masahiko Kishiro, Hideo Fukunaga, Masahiro Ohtsuki, Ken Takahashi, Katsumi Akimoto, Toshiaki Shimizu, Shiori Kawasaki, Toshio Kumasaka |
Journal | Pediatric cardiology
(Pediatr Cardiol)
Vol. 31
Issue 6
Pg. 773-9
(Aug 2010)
ISSN: 1432-1971 [Electronic] United States |
PMID | 20440486
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Sirolimus
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Topics |
- Animals
- Disease Models, Animal
- Drug-Eluting Stents
- Female
- Immunosuppressive Agents
(pharmacology)
- Pulmonary Veno-Occlusive Disease
(diagnosis, surgery)
- Secondary Prevention
- Sirolimus
(pharmacology)
- Treatment Outcome
- Tunica Intima
(drug effects, pathology)
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