Malignant neoplasms in rats fed lasiocarpine.

Abstract	Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumours included malignant adnexas tumour of the skin (1 rat) and lympohoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma. From one animal, angiosarcoma was successfully transplanted through 4 generations.
Authors	M S Rao, J K Reddy
Journal	British journal of cancer (Br J Cancer) Vol. 37 Issue 2 Pg. 289-93 (Feb 1978) ISSN: 0007-0920 [Print] England
PMID	204322 (Publication Type: Journal Article)
Chemical References	Carcinogens Pyrrolizidine Alkaloids lasiocarpine
Topics	Animals Carcinogens Carcinoma, Hepatocellular (chemically induced) Hemangiosarcoma (chemically induced) Liver Neoplasms (chemically induced) Male Neoplasms (chemically induced) Plants, Toxic Pyrrolizidine Alkaloids (toxicity) Rats Rats, Inbred F344 Senecio

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