[Therapeutic trial with ivermectin in loiasis with medium and high microfilaremia].

Abstract

Treatment with ivermectin at the dosage of 200 microgram/kg in 28 Congolese loiasis patients led to an important decrease of the microfilaremia on day 7, with a reduction of about 90% of the initial parasite load. However, no negativation was observed and, moreover, the parasitemia did not change from day 7 to day 14. Tolerance was quite good, but weak to moderate reactions, linked to the lysis of the microfilariae, were observed in one third of the patients with a microfilaremia greater or equal to 2,500/mm3.

• Authors: B Carme, B Ebikili, A Mbitsi, N Copin
• Journal: Annales de la Societe belge de medecine tropicale (Ann Soc Belg Med Trop) Vol. 71 Issue 1 Pg. 47-50 (Mar 1991) ISSN: 0772-4128 [Print] Belgium
• Vernacular Title: Essai thérapeutique de l'ivermectine au cours de la loase à moyenne et forte microfilarémie.
• PMID: 2043000 (Publication Type: Journal Article)

Chemical References

• Ivermectin

Topics

• Animals
• Dose-Response Relationship, Drug
• Humans
• Ivermectin (administration & dosage, therapeutic use)
• Loiasis (drug therapy, parasitology)
• Microfilariae (isolation & purification)