[ENPP1 K121Q polymorphism and ischemic heart disease in diabetic patients].

Abstract

BACKGROUND:

The ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) gene is a candidate gene for insulin resistance. Insulin resistance is a major component of metabolic syndrome (MetS) and has been implicated in ischemic heart disease (IHD).

OBJECTIVE:

To evaluate the association between the K121Q polymorphism of the ENPP1 gene and IHD in white patients with type 2 diabetes mellitus (DM).

METHODS:

A cross-sectional study was performed in type 2 DM patients (n = 573, 50.6% males, age 59.5+/-10.4 years). IHD was defined by the presence of angina or myocardial infarction according to the Worth Health Organization cardiovascular questionnaire and/or compatible electrocardiographic (Minnesota Code), or perfusional abnormalities in myocardial scintigraphy. The K121Q polymorphism of ENPP1 gene was genotyped using PCR-based methods and restriction enzyme digestion.

RESULTS:

IHD was present in 209 (36.5%) patients. The distribution of KK, KQ and QQ genotypes among patients with IHD was 60.8%, 34.4% and 4.8%, not different from the genotype distribution in the group without IHD (64%, 32.7% and 3.3%, P=0.574). No difference was found in the clinical and laboratory characteristics between the three genotypes, neither regarding the prevalence of Metabolic Syndrome.

CONCLUSION:

No association was found between polymorphism K121A of ENPP1 gene and the presence of IHD.

• Authors: Milene Moehlecke, Caroline K Kramer, Cristiane B Leitão, Ana Luiza Krahe, Ivaldir Balbosco, Mirela Jobim de Azevedo, Jorge L Gross, Luis Henrique Canani
• Journal: Arquivos brasileiros de cardiologia (Arq Bras Cardiol) Vol. 94 Issue 2 Pg. 157-61, 168-73, 159-63 (Feb 2010) ISSN: 1678-4170 [Electronic] Brazil
• PMID: 20428609 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Phosphoric Diester Hydrolases
• ectonucleotide pyrophosphatase phosphodiesterase 1
• Pyrophosphatases

Topics

• Diabetes Mellitus, Type 2 (complications)
• Epidemiologic Methods
• Female
• Humans
• Male
• Metabolic Syndrome (genetics)
• Middle Aged
• Myocardial Ischemia (genetics)
• Phosphoric Diester Hydrolases (genetics)
• Polymorphism, Genetic (genetics)
• Pyrophosphatases (genetics)
• White People (genetics)