Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum.

Abstract

Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3',4'-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques.

• Authors: Gwendoline Cheng Lian Ee, Chyi Meei Lim, Mawardi Rahmani, Khozirah Shaari, Choon Fah Joseph Bong
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 15 Issue 4 Pg. 2398-404 (Apr 05 2010) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 20428051 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 5-(3,4-(methylenedioxy)phenyl)-pent-2-ene piperidine
• Alkaloids
• Antineoplastic Agents
• Benzodioxoles
• Fatty Acids, Unsaturated
• Piperidines
• Polyunsaturated Alkamides
• pellitorine
• piperine

Topics

• Alkaloids (metabolism)
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Benzodioxoles (chemistry, metabolism, pharmacology)
• Cell Line, Tumor
• Fatty Acids, Unsaturated (chemistry, isolation & purification, pharmacology)
• Humans
• Piper nigrum (chemistry)
• Piperidines (chemistry, metabolism, pharmacology)
• Polyunsaturated Alkamides (chemistry, isolation & purification, metabolism, pharmacology)