Enantioanalysis of (-)butaclamol using vancomycin and teicoplanin as chiral selectors.

Abstract

Butaclamol is an antipsychotic drug used in the treatment of schizophrenia. The macrocyclic antibiotics, vancomycin and teicoplanin, are proposed as chiral selectors for the design of the enantioselective, potentiometric membrane electrodes (EPMEs) for the assay of (-)butaclamol. The slopes of the electrodes are near-Nernstian for the assay of (-) butaclamol with linear concentration ranges between 10(-10) and 10(-7) mol/L and between 10(-9) and 10(-7) mol/L for vancomycin and teicoplanin based EPMEs. Limits of detections varied. The electrodes were used reliably for the enantioanalysis of (-) butaclamol in serum samples.

• Authors: Raluca-Ioana Stefan-van Staden, Nontete Suzan Nhlapo, Jacobus Frederick van Staden, Hassan Y Aboul-Enein
• Journal: Combinatorial chemistry & high throughput screening (Comb Chem High Throughput Screen) Vol. 13 Issue 8 Pg. 690-3 (Sep 2010) ISSN: 1875-5402 [Electronic] United Arab Emirates
• PMID: 20426737 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Antipsychotic Agents
• Teicoplanin
• Vancomycin
• Butaclamol

Topics

• Anti-Bacterial Agents (analysis, chemistry)
• Antipsychotic Agents (analysis, chemistry)
• Butaclamol (analysis, chemistry)
• Electrodes
• Humans
• Hydrogen-Ion Concentration
• Molecular Structure
• Potentiometry
• Stereoisomerism
• Teicoplanin (analysis, chemistry)
• Vancomycin (analysis, chemistry)