Evaluating the porcine dermis graft InteXen in three-compartment transvaginal pelvic organ prolapse repair.

Abstract

INTRODUCTION AND HYPOTHESIS:

The aim was to assess the efficacy of three-compartment pelvic organ prolapse (POP) vaginal repair using the InteXen biocompatible porcine dermal graft as compared to traditional colporrhaphy with sacrospinous ligament suspension.

METHODS:

Preoperative, operative, postoperative and follow-up data were collected retrospectively. Objective recurrence was defined as POP quantification >or= stage II and subjective recurrence as a symptomatic bulge.

RESULTS:

Each group consisted of 63 patients. Surgery time was longer using InteXen (72 +/- 24.5 vs 55 +/- 23.5 min, p = 0.0002). Length of hospital stay (4.6 +/- 1.6 vs 4.9 +/- 2.1 days, p = 0.34) as well as duration of follow-up (37.1 vs 35.7 months, p = 0.45) were equivalent between the two groups. No case of mesh erosion or infection was noted. The objective (17% vs 8%, p = 0.12) and subjective recurrence rates (13% vs 5%, p = 0.12) between the two groups were not statistically different.

CONCLUSIONS:

InteXen was well tolerated but had similar efficacy to traditional colporrhaphy and sacrospinous ligament suspension.

• Authors: Rajeev Ramanah, Julian Mairot, Marie-Caroline Clement, Bernard Parratte, Robert Maillet, Didier Riethmuller
• Journal: International urogynecology journal (Int Urogynecol J) Vol. 21 Issue 9 Pg. 1151-6 (Sep 2010) ISSN: 1433-3023 [Electronic] England
• PMID: 20424823 (Publication Type: Comparative Study, Journal Article)

Topics

• Bioprosthesis
• Dermis (transplantation)
• Female
• Gynecologic Surgical Procedures (methods)
• Humans
• Middle Aged
• Pelvic Organ Prolapse (surgery)
• Prosthesis Design
• Recurrence
• Treatment Outcome
• Vagina (surgery)