Abstract | BACKGROUND: METHODS: We prospectively studied 10 episodes of unprovoked ICP rise in 7 patients treated with 85 ml of 8.4% sodium bicarbonate in place of our usual 100 ml 5% saline. We measured ICP and mean arterial pressure continuously for 6 h after infusion. Serum pH, pCO(2), [Na(+)], and [Cl(-)] were measured at baseline, 30 min, 60 min and then hourly for 6 h. RESULTS: At the completion of the infusion (t = 30 min), the mean ICP fell from 28.5 mmHg (+/-2.62) to 10.33 mmHg (+/-1.89), P < 0.01. Mean ICP remained below 20 mmHg at all time points for 6 h. Mean arterial pressure was unchanged leading to an increased cerebral perfusion pressure at all time points for 6 h post-infusion. pH was elevated from 7.45 +/- 0.05 at baseline to 7.50 +/- 0.05, P < 0.01 at t = 30 min, and remained elevated. Serum [Na(+)] increased from 145.4 +/- 6.02 to 147.1 +/- 6.3 mmol/l, P < 0.01 at t = 30 min. pCO(2) did not change. CONCLUSIONS:
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Authors | Chris Bourdeaux, Jules Brown |
Journal | Neurocritical care
(Neurocrit Care)
Vol. 13
Issue 1
Pg. 24-8
(Aug 2010)
ISSN: 1556-0961 [Electronic] United States |
PMID | 20422466
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chlorides
- Sodium Bicarbonate
- Sodium
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Topics |
- Blood Pressure
(drug effects)
- Brain Injuries
(blood, drug therapy, physiopathology)
- Catheterization, Central Venous
- Cerebrovascular Circulation
(drug effects)
- Chlorides
(blood)
- Humans
- Hydrogen-Ion Concentration
(drug effects)
- Intracranial Pressure
(drug effects)
- Prospective Studies
- Sodium
(blood)
- Sodium Bicarbonate
(administration & dosage)
- Time Factors
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