Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: The whole plant of Enicostemma axillare Raynal (Family: Gentianaceae) is used in variety of diseases in traditional Indian system of medicine including hepatic ailments. AIM OF THE STUDY:
Swertiamarin isolated from Enicostemma axillare Raynal was evaluated for antioxidant and hepatoprotective activity. MATERIALS AND METHODS: RESULTS:
Swertiamarin a secoiridoid glycoside was found to contain a major constituent of the extract. d-GalN caused significant hepatotoxicity by alteration of several hepatic parameters. It also caused significant lipid peroxidation and reduced the levels of antioxidant defense mechanisms. The treatment with swertiamarin at 100 and 200mg/kg body weight when administered orally for 8 days prior to d-GalN caused a significant restoration of all the altered biochemical parameters due to d-GalN towards the normal, indicating the potent antioxidant and hepatoprotective nature of swertiamarin. CONCLUSIONS:
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Authors | V Jaishree, Shrishailappa Badami |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 130
Issue 1
Pg. 103-6
(Jul 06 2010)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 20420896
(Publication Type: Journal Article)
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Copyright | Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Antioxidants
- Glucosides
- Iridoid Glucosides
- Iridoids
- Plant Extracts
- Pyrones
- swertiamarin
- Galactosamine
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Female
- Galactosamine
(toxicity)
- Gentianaceae
(chemistry)
- Glucosides
(pharmacology)
- Iridoid Glucosides
- Iridoids
(pharmacology)
- Liver
(drug effects)
- Male
- Plant Extracts
(pharmacology)
- Pyrones
(pharmacology)
- Rats
- Rats, Wistar
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