Melatonin-analog, beta-methyl-6-chloromelatonin, supplementation in spinal cord injury.

Abstract

Spinal cord injury (SCI) is a devastating condition. Melatonin supplementation has been shown to lessen SCI, but its use has been limited by its side effect profile. In this work, rats underwent a moderate-to-severe contussional SCI with either placebo or beta-methyl-6-chloromelatonin, 10mg/kg or 100mg/kg supplementation. The 10mg/kg supplementation demonstrated benefit; the 100mg/kg dosage was limited by toxicity. This is the first work to assess a melatonin analog in SCI.

• Authors: Dominic B Fee, Karin R Swartz, Nicole Scheff, Kelly Roberts, Prasad Gabbita, Stephen Scheff
• Journal: Brain research (Brain Res) Vol. 1340 Pg. 81-5 (Jun 22 2010) ISSN: 1872-6240 [Electronic] Netherlands
• PMID: 20420812 (Publication Type: Journal Article)
• Copyright: (c) 2010 Elsevier B.V. All rights reserved.

Chemical References

• Neuroprotective Agents
• beta-methyl-6-chloromelatonin
• Melatonin

Topics

• Animals
• Dietary Supplements
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Female
• Melatonin (analogs & derivatives, therapeutic use, toxicity)
• Neurons (drug effects, metabolism, pathology)
• Neuroprotective Agents (therapeutic use, toxicity)
• Rats
• Rats, Sprague-Dawley
• Spinal Cord (drug effects, pathology)
• Spinal Cord Injuries (drug therapy, pathology)