Pachycladins A-E, prostate cancer invasion and migration inhibitory Eunicellin-based diterpenoids from the red sea soft coral Cladiella pachyclados.

Abstract	Alcyonaria species are among the important marine invertebrate classes that produce a wealth of chemically diverse bioactive diterpenes. Examples of these are the potent microtubule disruptor sarcodictyins and eleutherobin. The genus Cladiella has proven to be a rich source of cytotoxic eunicellin-based diterpenoids. Five new eunicellin diterpenes, pachycladins A-E (1-5), were isolated from the Red Sea soft coral Cladiella pachyclados. The known sclerophytin A Cladiellisin, 3-acetylcladiellisin, 3,6-diacetylcladiellisin, (+)-polyanthelin A, klysimplexin G, klysimplexin E, sclerophytin F methyl ether, (6Z)-cladiellin (cladiella-6Z,11(17)-dien-3-ol), sclerophytin B, and patagonicol were also identified. The structures of the isolated compounds were elucidated by extensive interpretation of their spectroscopic data. These compounds were evaluated for their ability to inhibit growth, proliferation, invasion, and migration of the prostate cancer cells PC-3. Some of the new metabolites exhibited significant anti-invasive activity.
Authors	Hossam M Hassan, Mohammad A Khanfar, Ahmed Y Elnagar, Rabab Mohammed, Lamiaa A Shaala, Diaa T A Youssef, Mohamed S Hifnawy, Khalid A El Sayed
Journal	Journal of natural products (J Nat Prod) Vol. 73 Issue 5 Pg. 848-53 (May 28 2010) ISSN: 1520-6025 [Electronic] United States
PMID	20420415 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents Bridged-Ring Compounds Diterpenes Furans eleutherobin eunicellin sclerophytin F patagonicol
Topics	Animals Anthozoa (chemistry) Antineoplastic Agents (chemistry, isolation & purification, pharmacology) Bridged-Ring Compounds (chemistry) Cell Movement (drug effects) Cell Proliferation (drug effects) Diterpenes (chemistry, isolation & purification, pharmacology) Drug Screening Assays, Antitumor Furans (chemistry) Humans Indian Ocean Male Marine Biology Molecular Structure Prostatic Neoplasms (drug therapy) Stereoisomerism Structure-Activity Relationship Wound Healing (drug effects)

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