Abstract | OBJECTIVE: METHODS: Eight concentrations of methylnicotinate were applied to the forearms of 20 adults with schizophrenia and 20 controls. Laser Doppler measurement of blood flow responses was used to derive values for niacin sensitivity (defined as the concentration eliciting half-maximal response, i.e., EC(50) value) and efficacy (defined as the maximal evoked blood flow response). RBC membrane fatty acids were analyzed by gas chromatography. RESULTS: CONCLUSIONS:
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Authors | Erik Messamore, William F Hoffman, Jeffrey K Yao |
Journal | Schizophrenia research
(Schizophr Res)
Vol. 122
Issue 1-3
Pg. 248-56
(Sep 2010)
ISSN: 1573-2509 [Electronic] Netherlands |
PMID | 20417059
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | (c) 2010 Elsevier B.V. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Erucic Acids
- Fatty Acids, Omega-6
- Fatty Acids, Unsaturated
- Nicotinic Acids
- adrenic acid
- Niacin
- Arachidonic Acid
- methyl nicotinate
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Topics |
- Adult
- Anti-Inflammatory Agents
(pharmacology)
- Arachidonic Acid
(metabolism)
- Dose-Response Relationship, Drug
- Erucic Acids
(metabolism)
- Fatty Acids, Omega-6
(metabolism)
- Fatty Acids, Unsaturated
- Female
- Flushing
(chemically induced, metabolism)
- Humans
- Male
- Middle Aged
- Models, Biological
- Niacin
(pharmacology)
- Nicotinic Acids
(pharmacology)
- Regression Analysis
- Schizophrenia
(blood, physiopathology)
- Skin
(blood supply, drug effects)
- Skin Tests
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