The overlap of interstitial cystitis/painful bladder syndrome and overactive bladder.

Abstract

OBJECTIVE:

We evaluated the prevalence of positive potassium sensitivity and cystoscopy with hydrodistention findings in patients with overactive bladder.

METHOD:

This was a prospective cohort study of 98 patients who presented with overactive bladder symptoms. The diagnosis of overactive bladder is established by the presence of irritable voiding symptoms. All patients completed a PUF questionnaire and underwent potassium sensitivity testing. Eighty patients underwent urodynamic testing, and 42 patients underwent cystoscopic hydrodistention while under general anesthesia.

RESULTS:

The Potassium Sensitivity Test was positive in 59 (60.2%) of the 98 patients, 37 (56%) of wet overactive bladder patients, and 22 (68.8%) of dry overactive bladder patients. Their mean PUF score was 7. Thirty-three (78.5%) of the patients who underwent cystoscopic hydrodistention had glomerulations consistent with NIH criteria for interstitial cystitis, and 26 of these patients tested positive for potassium sensitivity. Fifty-one (63.8%) of the patients who underwent urodynamics tested positive for potassium sensitivity.

CONCLUSION:

Many patients with symptoms of overactive bladder with little or no pain have cystoscopic evidence of interstitial cystitis and a positive Potassium Sensitivity Test. Therapies directed toward the uroepithelial dysfunction and neural upregulation associated with interstitial cystitis/painful bladder syndrome may be an important adjunct for patients who have failed or have had a partial response to anticholinergic therapy and behavior modification.

• Authors: Maurice K Chung, Charles W Butrick, Cherie W Chung
• Journal: JSLS : Journal of the Society of Laparoendoscopic Surgeons (JSLS) 2010 Jan-Mar Vol. 14 Issue 1 Pg. 83-90 ISSN: 1086-8089 [Print] United States
• PMID: 20412643 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Cystitis, Interstitial (diagnosis, epidemiology, physiopathology)
• Cystoscopy
• Female
• Humans
• Male
• Middle Aged
• Urinary Bladder, Overactive (diagnosis, epidemiology, physiopathology)
• Urinary Incontinence (epidemiology, physiopathology)
• Urodynamics
• Young Adult