Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07).

Abstract

OBJECTIVE:

To evaluate the efficacy of a novel immunomodulating peptide (SCV-07) in attenuating the course of radiation-induced mucositis in an established animal model of oral mucositis (OM).

MATERIAL AND METHODS:

In three separate experiments, golden Syrian hamsters received either an acute radiation challenge to the buccal mucosa of eight fractionated doses of 7.5 Gy of radiation over a 2-week-period, or a combination of acute radiation and cisplatin. In each experiment, animals were treated with varying doses or schedules of SCV-07 or placebo. OM was scored in a blinded fashion using digital images obtained during the experimental period.

RESULTS:

We found that SCV-07 reduced the severity and duration of both acute and fractionated radiation-induced OM. Similarly, when radiation and chemotherapy were used to induce OM, treatment with SCV-07 significantly reduced the duration of ulcerative OM. The therapeutic benefit was dependent on both dose and schedule of administration.

CONCLUSION:

Taken together, we found SCV-07 was able to modify the duration and severity of oral mucositis and was dependent on schedule and dose.

• Authors: B Watkins, K Pouliot, E Fey, C Tuthill, S Sonis
• Journal: Oral diseases (Oral Dis) Vol. 16 Issue 7 Pg. 655-60 (Oct 2010) ISSN: 1601-0825 [Electronic] Denmark
• PMID: 20412446 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Dipeptides
• Immunologic Factors
• Placebos
• golotimod
• Cisplatin

Topics

• Animals
• Antineoplastic Agents (adverse effects)
• Cisplatin (adverse effects)
• Cricetinae
• Dipeptides (administration & dosage, therapeutic use)
• Disease Models, Animal
• Dose Fractionation, Radiation
• Dose-Response Relationship, Drug
• Gingivitis, Necrotizing Ulcerative (chemically induced, etiology, prevention & control)
• Immunologic Factors (administration & dosage, therapeutic use)
• Male
• Mesocricetus
• Mouth Mucosa (drug effects, radiation effects)
• Oral Ulcer (chemically induced, etiology, prevention & control)
• Placebos
• Radiotherapy (adverse effects)
• Single-Blind Method
• Stomatitis (chemically induced, etiology, prevention & control)
• Time Factors