Abstract | AIM: METHODS: RESULTS: Masson's staining of rat livers showed fibrosis around pseudo-lobules in the CCl(4) group, the lesions being reduced in the CCl(4) HTHQ group. Increases in liver tissue hydroxyproline and alpha(1)(I) collagen, alpha-smooth muscle actin and iNOS induced by CCl(4), were also markedly diminished by HTHQ. Furthermore, both HTHQ and vitamin E attenuated interleukin-1beta-induced iNOS protein expression in cultured hepatocytes, the potency of HTHQ being 10-times higher than that of vitamin E. CONCLUSION:
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Authors | Jun An, Guo-Gang Feng, Lei Huang, Tsuyoshi Kurokawa, Toshiaki Nonami, Tatsuro Koide, Fumio Kondo, Toru Komatsu, Koji Tsunekawa, Yoshihiro Fujiwara, Hidemi Goto, Hiroshi Nishikawa, Tokutaro Miki, Satoru Sugiyama, Naohisa Ishikawa |
Journal | Hepatology research : the official journal of the Japan Society of Hepatology
(Hepatol Res)
Vol. 40
Issue 6
Pg. 613-21
(Jun 2010)
ISSN: 1872-034X [Electronic] Netherlands |
PMID | 20412328
(Publication Type: Journal Article)
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