Abstract | OBJECTIVES: METHODS: We recruited patients with severe snoring and apneic episodes willing to undergo repeated nocturnal oximetry testing. Following baseline clinical history, Epworth Sleepiness Scale administration, and home overnight nocturnal oximetry, patients were started on weight-adjusted doses of domperidone and pseudoephedrine. Follow-up oximetry studies were performed at the patient's convenience. On the final visit, a repeat clinical history, Epworth score, and oximetry were obtained. RESULTS: Seventeen of 23 patients noted disappearance of snoring and apneic episodes. Another 2 patients reported improvement in snoring and no apneic episodes. All but one patient had a decrease in Epworth scores (mean decrease 9.4 (95% CI, 6.8-12.1, p < 0.0001). Mean oxygen saturation (2.5; 95% Cl, 0.66-4.41, p = 0.008), percent time with oxygen saturation < 90% (14.8; 95% CI, 24.4 to 5.2, p = 0.003), and the 4% oxygen desaturation index (18.2; 95% CI, 27.3 to 9.1, p < 0.0001) improved significantly. No adverse effects of treatment were noted. CONCLUSIONS: KEYWORDS: CITATION:
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Authors | Augusto Larrain, Vishesh K Kapur, Ted A Gooley, Charles E Pope 2nd |
Journal | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
(J Clin Sleep Med)
Vol. 6
Issue 2
Pg. 117-23
(Apr 15 2010)
ISSN: 1550-9389 [Print] United States |
PMID | 20411686
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiemetics
- Bronchodilator Agents
- Domperidone
- Pseudoephedrine
- Oxygen
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Topics |
- Adult
- Aged
- Antiemetics
(therapeutic use)
- Bronchodilator Agents
(therapeutic use)
- Domperidone
(therapeutic use)
- Drug Therapy, Combination
(methods)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Oximetry
(methods)
- Oxygen
(metabolism)
- Pseudoephedrine
(therapeutic use)
- Sleep Apnea, Obstructive
(drug therapy)
- Treatment Outcome
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